Core concepts are explained in a friendly, down-to-earth tone, with frequent comparisons to similar aspects of English. Like its predecessor, Human Japanese Intermediate is built on the idea that the best way to learn and truly comprehend Japanese is to have it explained by someone who speaks your language. INGREDIENTS™ example sentence breakdowns for total clarity in every example Intelligent quizzes that track your history and help you focus on trouble spots Photos and cultural notes to keep you engaged and energized Kanji animations, tips, illustrations, and more Over 2600 example sentences and dialogs with crystal-clear recordings of male and female speech
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(And if you're new to Human Japanese, welcome aboard! Find a full list of content by chapter at In Human Japanese Intermediate, you'll find: If you liked the first HJ, you'll love Intermediate.
Human Japanese Intermediate is packed with content and features that will take your Japanese language skills to the next level. The adult mouse was also found to have improved cognitive function with the increase in neural stem cell multiplication.Learn Japanese with the long-awaited sequel to Human Japanese! The engineered neural stem cells in an adult mouse became more active in comparison to the almost total absence of any multiplication of such cells in normal adult mice and the neural stem cells continued to multiply for about three months. The team used it to genetically engineer cells in the brains of an adult mouse. The team came up with its iPaD method that would lead to the maximum activation of the neural stem cells by combining the genes in infant mice that were most active with a restraining function on the most active genes in adult mice. The researchers also found that neural stem cells in the adult mouse could be made to be more active by restraining the genes that are most active in adult mice neural stem cells. Of the 80 types of genes active in the infant mouse, the team was able to pinpoint those genes that contributed to greater activity by the neural stem cells. The team compared the genes present in the neural stem cells in the brains of an infant mouse and an adult mouse. That, in turn, results in reduced cognitive function. The procedure may not be easily applied to humans because the genetic engineering of the mouse involved the use of a virus to inject the genes into the brain.īut Kageyama said efforts would continue to see if the procedure can be eventually applied to humans because the results of the test on a mouse was equivalent to turning “the neural stem cells of a human in their 60s into those of a teenager.”Įmbryonic neural stem cells multiply rapidly to increase the number of nerve cells, but that ability to multiply weakens with age. The team will now test its method, dubbed "iPaD," on marmosets to determine if it can be applied to primates. The team sought to regenerate neural stem cells that create nerve cells, but which also weaken with age. The research team was led by Ryoichiro Kageyama, a visiting professor at Kyoto University’s Institute for Frontier Life and Medical Sciences. Researchers at Kyoto University have succeeded in regenerating neural stem cells in an adult mouse and improving its cognitive function, which offers hope that the method could eventually be applied to humans.